In collaboration with the Department of Medicine, several members of our department are collaborating on a number of large, multicentre clinical trials. The VISION study is a prospective cohort study of 40,000 patients, aged 45 years or older, having non-cardiac surgery that investigates the incidence of major vascular events and the optimal clinical model to predict these events. The POISE-2 study is a large, multicentre randomized controlled trial that is designed to determine the impact of ASA and clonidine on vascular death and non-fatal MI amongst patients having non-cardiac surgery.